Factors associated with short-term survival in neonates with hyperammonemia.

ABSTRACT:

Background

Hyperammonemia due to inherited metabolic disease can lead to neurological sequelae and death in neonates. Metabolite scavenger (MS) administration and dialysis can be helpful. We aim at analyzing the factors affecting short-term survival in neonates with hyperammonemia.

Methods

We conducted a retrospective study including all neonates with hyperammonemia admitted to the neonatal intensive care unit (NICU) of the Children's Hospital of Fudan University between April 2013 and June 2020.

Results

Sixty-two neonates were enrolled in the study. Of these, 32 neonates were included in the non-survival group, and 30 neonates in the survival group. Compared to the survival group, the non-survival group had a higher peak ammonia level (882.2 vs. 433.4 µmol/L)

SUBMITTER: Qiu H 

PROVIDER: S-EPMC9834949 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature