A metabolomic-based biomarker discovery study for predicting phototherapy duration for neonatal hyperbilirubinemia.

ABSTRACT:

Background

Phototherapy is a recommended method for the treatment of neonatal hyperbilirubinemia. However, biomarkers for predicting the more effective duration of phototherapy prior to treatment are lacking. Therefore, we aimed to determine novel predictors for the timing of phototherapy from the perspective of metabolomics.

Methods

A total of 12 newborns with neonatal hyperbilirubinemia were recruited on the day of admission. The infants were divided into a short-duration (<30 hours) phototherapy group and a long-duration (≥30 hours) phototherapy group based on the length of phototherapy treatment. Metabolites in serum samples were then explored using an untargeted metabolomics strategy.

Results

In total, 59 of 1,073 significantly different metabolites were identifi

SUBMITTER: Zhu D 

PROVIDER: S-EPMC9834951 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature