Inhaled particulate accumulation with age impairs immune function and architecture in human lung lymph nodes.

ABSTRACT: Older people are particularly susceptible to infectious and neoplastic diseases of the lung and it is unclear how lifelong exposure to environmental pollutants affects respiratory immune function. In an analysis of human lymph nodes (LNs) from 84 organ donors aged 11-93 years, we found a specific age-related decline in lung-associated, but not gut-associated, LN immune function linked to the accumulation of inhaled atmospheric particulate matter. Increasing densities of particulates were found in lung-associated LNs with age, but not in the corresponding gut-associated LNs. Particulates were specifically contained within CD68⁺CD169^- macrophages, which exhibited decreased activation, phagocytic capacity, and altered cytokine production compared with non-particulate-con

SUBMITTER: Ural BB 

PROVIDER: S-EPMC9835154 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature