Current Update on Rotavirus in-Silico Multiepitope Vaccine Design.

ABSTRACT: Rotavirus gastroenteritis is one of the leading causes of pediatric morbidity and mortality worldwide in infants and under-five populations. The World Health Organization (WHO) recommended global incorporation of the rotavirus vaccine in national immunization programs to alleviate the burden of the disease. Implementation of the rotavirus vaccination in certain regions of the world brought about a significant and consistent reduction of rotavirus-associated hospitalizations. However, the efficacy of licensed vaccines remains suboptimal in low-income countries where the incidences of rotavirus gastroenteritis continue to happen unabated. The problem of low efficacy of currently licensed oral rotavirus vaccines in low-income countries necessitates continuous exploration, design, and developm

SUBMITTER: Kuri PR 

PROVIDER: S-EPMC9835168 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature