Advancing the science on chemical classes.

ABSTRACT:

Background

Hazard identification, risk assessment, regulatory, and policy activity are usually conducted on a chemical-by-chemical basis. Grouping chemicals into categories or classes is an underutilized approach that could make risk assessment and management of chemicals more efficient for regulators.

Objective and methods

While there are some available methods and regulatory frameworks that include the grouping of chemicals (e.g.,same molecular mechanism or similar chemical structure) there has not been a comprehensive evaluation of these different approaches nor a recommended course of action to better consider chemical classes in decision-making. This manuscript: 1) reviews current national and international approaches to grouping; 2) describes how groups could be define

SUBMITTER: Maffini MV 

PROVIDER: S-EPMC9835214 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature