Efficacy and safety of corticosteroids in cardiac arrest: a systematic review, meta-analysis and trial sequential analysis of randomized control trials.

ABSTRACT:

Background

Post-cardiac arrest, outcomes for most patients are poor, regardless of setting. Many patients who do achieve spontaneous return of circulation require vasopressor therapy to maintain organ perfusion. There is some evidence to support the use of corticosteroids in cardiac arrest.

Research question

Assess the efficacy and safety of corticosteroids in patients following in- and out-of-hospital cardiac arrest.

Study design and methods

We searched databases CINAHL, EMBASE, LILACS, MEDLINE, Web of Science, CENTRAL, ClinicalTrails.gov, and ICTRP. We included randomized controlled trials (RCTs) that examined the efficacy and safety of corticosteroids, as compared to placebo or usual care in patients post-cardiac arrest. We pooled estimates of effect size using ran

SUBMITTER: Penn J 

PROVIDER: S-EPMC9835217 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature