Caspase-8 contributes to an immuno-hot microenvironment by promoting phagocytosis via an ecto-calreticulin-dependent mechanism.

ABSTRACT:

Background

Caspase-8 (Casp8) acts as an initiator in cell apoptosis signaling. However, the role of Casp8 in tuning the tumor immune microenvironment remains controversial due to the complicated crosstalk between immune-tolerogenic apoptotic cell death and immunogenic cell death cascades.

Methods

The Cancer Genome Atlas (TCGA) and publicly accessible immune checkpoint blockade (ICB)-treated cohorts were used to investigate the clinical relevance of Casp8. A tumor-bearing mouse model was used to characterize changes in the tumor microenvironment and to explore the efficacy of ICB treatment under Casp8 knockout conditions.

Results

By exploring TCGA datasets, we showed that the expression level of Casp8 was associated with an immuno-hot microenvironment across various so

SUBMITTER: Gong Z 

PROVIDER: S-EPMC9835222 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature