Advances in CRISPR Delivery Methods: Perspectives and Challenges.

ABSTRACT: With the advent of new genome editing technologies and the emphasis placed on their optimization, the genetic and phenotypic correction of a plethora of diseases sit on the horizon. Ideally, genome editing approaches would provide long-term solutions through permanent disease correction instead of simply treating patients symptomatically. Although various editing machinery options exist, the clustered regularly interspaced short palindromic repeats (CRISPR)-Cas (CRISPR-associated protein) editing technique has emerged as the most popular due to its high editing efficiency, simplicity, and affordability. However, while CRISPR technology is gradually being perfected, optimization is futile without accessible, effective, and safe delivery to the desired cell or tissue. Therefore, it is import

SUBMITTER: Demirci S 

PROVIDER: S-EPMC9835311 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature