Brain endothelial CXCL12 attracts protective natural killer cells during ischemic stroke.

ABSTRACT:

Background

The innate lymphoid cell (ILC) family consists of NK cells, ILC type 1, 2, 3 and lymphoid tissue inducer cells. They have been shown to play important roles in homeostasis and immune responses and are generally considered tissue resident. Not much is known about the presence of ILC members within the central nervous system and whether they are tissue resident in this organ too. Therefore, we studied the presence of all ILC members within the central nervous system and after ischemic brain insult.

Methods

We used the photothrombotic ischemic lesion method to induce ischemic lesions within the mouse brain. Using whole-mount immunofluorescence imaging, we established that the ILCs were present at the rim of the lesion. We quantified the increase of all ILC members at

SUBMITTER: Wang S 

PROVIDER: S-EPMC9835334 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature