Hypertension contributes to exacerbated osteoarthritis pathophysiology in rats in a sex-dependent manner.

ABSTRACT:

Background

Hypertension is a common comorbidity of osteoarthritis (OA) with known autonomic dysregulation; thus, the autonomic nervous system may provide a shared underlying mechanism. The objective of this study was to examine the role of the autonomic nervous system in a preclinical model of OA and hypertension.

Methods

Experiments were conducted in spontaneously hypertensive rats and a normotensive control strain, including male and female rats. OA was surgically induced via medial meniscus transection with skin incision used as a sham control (n = 7-8/strain/sex/surgery). Tactile sensitivity, anxiety-related behavior, and serum corticosterone were measured at baseline then bi-weekly across 8 weeks. At weeks 9-10, cardiovascular responses to a chemical vagal nerve agonist

SUBMITTER: Yeater TD 

PROVIDER: S-EPMC9835335 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature