A noninvasive model discriminating significant histological changes in treatment-naive chronic hepatitis B patients with normal ALT.

ABSTRACT: Traditionally part of chronic hepatitis B (CHB) patients with normal alanine aminotransferase (ALT) are recommended to antiviral therapy referring to liver biopsy. However, liver biopsy is an invasive method with various potential complications. A noninvasive model was established in the study to evaluate liver histology and to identify the need of antiviral therapy. A total of 614 liver biopsied CHB patients with ALT less than upper limit of normal from 2 centers were retrospectively analyzed. They were divided into a training cohort and a validation cohort. A noninvasive model to predict the significant liver histological changes was established and validated. The results of analysis showed that ALT, Age, platelet (PLT) and liver stiffness (LS) were independent risk factors for significa

SUBMITTER: Teng J 

PROVIDER: S-EPMC9835358 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature