Vaccines against leishmaniasis: using controlled human infection models to accelerate development.

ABSTRACT:

Introduction

Leishmaniasis is a neglected tropical disease that is defined by the World Health Organization as vaccine preventable. Although several new candidate vaccines are in development, no vaccine has successfully reached the market for human use. Several species of Leishmania cause human disease and have co-evolved with their respective sand fly vectors. These unique relationships have implications for initiation of infection and vaccine development. An approach to vaccine development for many infectious diseases is the use of controlled human infection models (CHIMs).

Areas covered

We describe the history and recent development of experimental and deliberate infection using Leishmania in humans and the rationale for developing a new sand fly-initiated C

SUBMITTER: Parkash V 

PROVIDER: S-EPMC9835556 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature