Antiretroviral protease inhibitors induce features of cellular senescence that are reversible upon drug removal.

ABSTRACT: Antiretroviral drugs have dramatically improved the prognosis of HIV-infected patients, with strikingly reduced morbidity and mortality. However, long-term use can be associated with signs of premature aging. Highly active antiretroviral therapy generally comprises two nucleoside reverse transcriptase inhibitors (NRTIs), with one of three additional antiretroviral drug classes, including protease inhibitors (PIs). One commonality between mitochondrial dysfunction (induced by NRTIs) and defects in lamin A (induced by PIs) is they can cause or accelerate cellular senescence, a state of essentially irreversible growth arrest, and the secretion of many bioactive molecules collectively known as the senescence-associated secretory phenotype (SASP). We hypothesized that senescent cells increase f

SUBMITTER: Kuehnemann C 

PROVIDER: S-EPMC9835573 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature