Protective Effect of Tea Saponins on Alcohol-Induced Gastric Mucosal Injury in Mice.

ABSTRACT: Excessive alcohol consumption harms the human body, particularly the digestive system, by causing damage to the gastric mucosa. Tea saponin is a natural active substance extracted from tea tree seeds that has gastroprotective potential against alcohol-induced mucosal damage. However, the protective mechanism of tea saponins is not fully understood. The current study aimed to explore the protective mechanism of tea saponins against alcohol-induced gastric mucosal injury in mice. Histopathological changes, immunohistochemistry, immunoblotting, and gastric mucosa-related cytokine levels were analyzed in three groups of male mice: model, control, and tea saponin-treated. Compared to the model group, the tea saponin group prominently ameliorated alcohol-induced gastric mucosal injury by improvi

SUBMITTER: Shi Z 

PROVIDER: S-EPMC9835626 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature