Glycerol and Antimicrobial Peptide-Modified Natural Latex for Bacteriostasis of Skin Wounds.

ABSTRACT: This work aimed to develop a glycerol antimicrobial peptide natural latex film (NRL-GI-AMP film) for the treatment of skin wound infections. The contents of this work mainly include investigating the effect of adding glycerol (GI) and an antimicrobial peptide (AMP) on the physical and chemical properties of natural latex (NRL) and analyzing the cytocompatibility, bacteriostatic activity, and infected wound healing promotion of the NRL-GI-AMP film. The results showed that the addition of GI resulted in more pores in the internal structure of the NRL film, while the addition of G(LLKK)₃L AMP did not change the structure and properties of the NRL film. Compared with that of the NRL film, the infrared spectrum of the NRL-GI-AMP film did not produce new characteristic peaks, indicati

SUBMITTER: Wang R 

PROVIDER: S-EPMC9835661 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature