CDC1 coordinate innate and adaptive responses in the omentum required for T cell priming and memory.

ABSTRACT: In the peritoneal cavity, the omentum contains fat-associated lymphoid clusters (FALCs) whose role in response to infection is poorly understood. After intraperitoneal immunization with Toxoplasma gondii, conventional type 1 dendritic cells (cDC1s) were critical to induce innate sources of IFN-γ and cellular changes in the FALCs. Unexpectedly, infected peritoneal macrophages that migrated into the FALCs primed CD8⁺ T cells. Although T cell priming was cDC1 independent, these DCs were required for maximal CD8⁺ T cell expansion. An agent-based computational model and experimental data highlighted that cDC1s affected the magnitude of the proliferative burst and promoted CD8⁺ T cell expression of nutrient uptake receptors and cell survival. Thus, althoug

SUBMITTER: Christian DA 

PROVIDER: S-EPMC9835709 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature