Nasal host response-based screening for undiagnosed respiratory viruses: a pathogen surveillance and detection study.

ABSTRACT:

Background

Symptomatic patients who test negative for common viruses are an important possible source of unrecognised or emerging pathogens, but metagenomic sequencing of all samples is inefficient because of the low likelihood of finding a pathogen in any given sample. We aimed to determine whether nasopharyngeal CXCL10 screening could be used as a strategy to enrich for samples containing undiagnosed viruses.

Methods

In this pathogen surveillance and detection study, we measured CXCL10 concentrations from nasopharyngeal swabs from patients in the Yale New Haven health-care system, which had been tested at the Yale New Haven Hospital Clinical Virology Laboratory (New Haven, CT, USA). Patients who tested negative for a panel of respiratory viruses using multiplex PCR during

SUBMITTER: Cheemarla NR 

PROVIDER: S-EPMC9835789 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature