Gut mycobiome dysbiosis contributes to the development of hypertension and its response to immunoglobulin light chains.

ABSTRACT:

Objectives

Human gut microbiome has gained great attention for its proposed roles in the development of hypertension. The fungal microbiome in the human gut (i.e. the mycobiome) is beginning to gain recognition as a fundamental part of our microbiome. However, the existing knowledge of human mycobiome has never revealed the association between gut mycobiome and hypertension. It is known that inflammation and immunity contribute to human hypertension. Here, we sought to investigate whether gut mycobiome could predict the development of hypertension and its association with immunoglobulin light chains.

Methods and materials

Participants were classified into three cohorts: prehypertension (pre-HTN), hypertension (HTN), and normal-tension (NT) based on their blood pressure. Fres

SUBMITTER: Zou Y 

PROVIDER: S-EPMC9835811 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature