APOC3 Interference for Familial Chylomicronaemia Syndrome.
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ABSTRACT:
SUBMITTER: Hegele RA
PROVIDER: S-EPMC9835816 | biostudies-literature | 2022 Nov
REPOSITORIES: biostudies-literature
Publications
<i>APOC3</i> Interference for Familial Chylomicronaemia Syndrome.
TouchREVIEWS in endocrinology 20221102 2
Patients with familial chylomicronaemia syndrome (FCS) have severe hypertriglyceridaemia due to genetically absent lipolytic capacity. They have a poor response to conventional therapies. To reduce the risk of potentially fatal pancreatitis, the management of FCS relies principally on a strict low-fat diet, which is difficult to follow and compromises quality of life. Targeted reduction of apolipoprotein C-III using new anti-<i>APOC3</i> agents, such as the short interfering RNA ARO-APOC3, repre ...[more]
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