Controlling the Formation of Polyelectrolyte Complex Nanoparticles Using Programmable pH Reactions.

ABSTRACT: Enabling complexation of weak polyelectrolytes, in the presence of a programmable pH-modulation, offers a means to achieve temporal control over polyelectrolyte coassembly. Here, by mixing oppositely charged poly(allylamine hydrochloride) and poly(sodium methacrylate) in a (bi)sulfite buffer, nanoscopic complex coacervates are formed. Addition of formaldehyde initiates the formaldehyde-sulfite clock reaction, affecting the polyelectrolyte assembly in two ways. First, the abrupt pH increase from the reaction changes the charge density of the polyelectrolytes and thus the ratio of cationic and anionic species. Simultaneously, reactions between the polyamine and formaldehyde lead to chemical modifications on the polymer. Interestingly, core-shell polymeric nanoparticles are produced, which re

SUBMITTER: Sproncken CCM 

PROVIDER: S-EPMC9835975 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature