Effect of all-but-one conditional analysis for eQTL isolation in peripheral blood.

ABSTRACT: Expression quantitative trait locus detection has become increasingly important for understanding how noncoding variants contribute to disease susceptibility and complex traits. The major challenges in expression quantitative trait locus fine-mapping and causal variant discovery relate to the impact of linkage disequilibrium on signals due to one or multiple functional variants that lie within a credible set. We perform expression quantitative trait locus fine-mapping using the all-but-one approach, conditioning each signal on all others detected in an interval, on the Consortium for the Architecture of Gene Expression cohorts of microarray-based peripheral blood gene expression in 2,138 European-ancestry human adults. We contrast these results with traditional forward stepwise conditional

SUBMITTER: Brown M 

PROVIDER: S-EPMC9836021 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature