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Combining analytical epidemiology and genomic surveillance to identify risk factors associated with the spread of antimicrobial resistance in Salmonella enterica subsp. enterica serovar Heidelberg.


ABSTRACT: Antimicrobial resistance (AMR) has become a critical threat to public health worldwide. The use of antimicrobials in food and livestock agriculture, including the production of poultry, is thought to contribute to the dissemination of antibiotic resistant bacteria (ARB) and the genes and plasmids that confer the resistant phenotype (ARG). However, the relative contribution of each of these processes to the emergence of resistant pathogens in poultry production and their potential role in the transmission of resistant pathogens in human infections, requires a deeper understanding of the dynamics of ARB and ARG in food production and the factors involved in the increased risk of transmission.

SUBMITTER: Hetman BM 

PROVIDER: S-EPMC9836098 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature

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Combining analytical epidemiology and genomic surveillance to identify risk factors associated with the spread of antimicrobial resistance in <i>Salmonella enterica</i> subsp. <i>enterica</i> serovar Heidelberg.

Hetman Benjamin M BM   Pearl David L DL   Barker Dillon O R DOR   Robertson James J   Nash John H E JHE   Reid-Smith Richard R   Agunos Agnes A   Carrillo Catherine C   Topp Edward E   Van Domselaar Gary G   Parmley E Jane EJ   Bharat Amrita A   Mulvey Michael M   Allen Vanessa V   Taboada Eduardo N EN  

Microbial genomics 20221101 11


Antimicrobial resistance (AMR) has become a critical threat to public health worldwide. The use of antimicrobials in food and livestock agriculture, including the production of poultry, is thought to contribute to the dissemination of antibiotic resistant bacteria (ARB) and the genes and plasmids that confer the resistant phenotype (ARG). However, the relative contribution of each of these processes to the emergence of resistant pathogens in poultry production and their potential role in the tra  ...[more]

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