Circulating differentiated and senescent lymphocyte subsets and incident diabetes risk in older adults: The Cardiovascular Health Study.

ABSTRACT:

Introduction

Cellular senescence is a feature of aging implicated in the pathophysiology of diabetes mellitus (DM). Whether senescent lymphocytes are associated with the future occurrence of DM is uncertain.

Methods

We used cryopreserved peripheral blood mononuclear cells collected from 1860 Cardiovascular Health Study participants (average age 80.2 years) and flow cytometry immunophenotyping to evaluate the longitudinal relationships of naive (CD45RA⁺ ), memory (CD45RO⁺ ), senescent (CD28^- ), and T effector memory RA⁺ (TEMRA) (CD28^- CD57⁺ CD45RA⁺ ) CD4⁺ and CD8⁺ T cells, and memory B cells (CD19⁺ CD27⁺ ), with the risk of incident DM. In exploratory analy

SUBMITTER: Olson NC 

PROVIDER: S-EPMC9836256 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature