Impact of surface coating and systemic anticoagulants on hemostasis and inflammation in a human whole blood model.

ABSTRACT:

Background

Surface compatibility with blood is critical both for scientific investigations on hemostasis and clinical applications. Regarding in vitro and ex vivo investigations, minimal alteration in physiological hemostasis is of particular importance to draw reliable conclusions on the human coagulation system. At the same time, artificial coagulation activation must be avoided, which is relevant for the patient, for example to prevent stent graft occlusion. The aim was to evaluate the advantages and disadvantages of antithrombotic and antifouling surface coatings in the context of their suitability for ex vivo incubation and the study of coagulation properties.

Methods

We investigated the impact of different protocols for surface coating of synthetic material and differe

SUBMITTER: Spiegelburg DT 

PROVIDER: S-EPMC9836312 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature