CCL18 signaling from tumor-associated macrophages activates fibroblasts to adopt a chemoresistance-inducing phenotype.

ABSTRACT: The heterogeneity of cancer-associated fibroblasts (CAFs) might be ascribed to differences in origin. CD10 and GPR77 have been reported to identify a chemoresistance-inducing CAF subset in breast cancer. However, the precise mechanism for the formation of the CD10⁺GPR77⁺ CAFs remains unknown. In this study, we found that CCL18 expression was positively correlated with the density of CD10⁺GPR77⁺ CAFs in breast cancer and associated with a poor response to chemotherapy. Moreover, CCL18 secreted by tumor-associated macrophages (TAMs) activated a CD10⁺GPR77⁺ CAF phenotype in normal breast-resident fibroblasts (NBFs), which could then enrich cancer stem cells (CSCs) and induce chemoresistance in breast cancer cells. Mechanistical

SUBMITTER: Zeng W 

PROVIDER: S-EPMC9836934 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature