Complement Inhibition in Kidney Transplantation: Where Are We Now?

ABSTRACT: Kidney transplantation is a life-saving strategy for patients with end-stage renal disease. Although progress has been made in the field of transplantation medicine in recent decades in terms of surgical techniques and immunosuppression, long-term organ survival remains a challenge. Also, for reasons of organ shortage, there is an unmet need for new therapeutic approaches to improve the long-term survival of transplants. There is increasing evidence that the complement system plays a crucial role in various pathological events after transplantation, including ischemia/reperfusion injury as well as rejection episodes. The complement system is part of the innate immune system and plays a crucial role in the defense against pathogens but is also involved in tissue homeostasis. However, the ti

SUBMITTER: Vonbrunn E 

PROVIDER: S-EPMC9836999 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature