Deciphering genetic causes for sex differences in human health through drug metabolism and transporter genes.

ABSTRACT: Sex differences have been widely observed in human health. However, little is known about the underlying mechanism behind these observed sex differences. We hypothesize that sex-differentiated genetic effects are contributors of these phenotypic differences. Focusing on a collection of drug metabolism enzymes and transporters (DMET) genes, we discover sex-differentiated genetic regulatory mechanisms between these genes and human complex traits. Here, we show that sex-differentiated genetic effects were present at genome-level and at DMET gene regions for many human complex traits. These sex-differentiated regulatory mechanisms are reflected in the levels of gene expression and endogenous serum biomarkers. Through Mendelian Randomization analysis, we identify putative sex-differentiated cau

SUBMITTER: Huang Y 

PROVIDER: S-EPMC9837057 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature