Bicyclobutanes as unusual building blocks for complexity generation in organic synthesis.

ABSTRACT: Bicyclobutanes are among the most highly strained isolable organic compounds and their associated low activation barriers to reactivity make them intriguing building-blocks in organic chemistry. In recent years, numerous creative synthetic strategies exploiting their heightened reactivity have been presented and these discoveries have often gone hand-in-hand with the development of more practical routes for their synthesis. Their proclivity as strain-release reagents through their weak central C-C bond has been harnessed in a variety of addition, rearrangement and insertion reactions, providing rapid access to a rich tapestry of complex molecular scaffolds. This review will provide an overview of the different options available for bicyclobutane synthesis, the main classes of compounds tha

SUBMITTER: Golfmann M 

PROVIDER: S-EPMC9837078 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature