Genetic complementation fosters evolvability in complex fitness landscapes.

ABSTRACT: The ability of natural selection to optimize traits depends on the topology of the genotype-fitness map (fitness landscape). Epistatic interactions produce rugged fitness landscapes, where adaptation is constrained by the presence of low-fitness intermediates. Here, we used simulations to explore how evolvability in rugged fitness landscapes is influenced by genetic complementation, a process whereby different sequence variants mutually compensate for their deleterious mutations. We designed our model inspired by viral populations, in which genetic variants are known to interact frequently through coinfection. Our simulations indicate that genetic complementation enables a more efficient exploration of rugged fitness landscapes. Although this benefit may be undermined by genetic parasites,

SUBMITTER: Segredo-Otero E 

PROVIDER: S-EPMC9837146 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature