Mechanisms of cell injury induced by inhaled molybdenum trioxide nanoparticles in Golden Syrian Hamsters.

ABSTRACT: Molybdenum trioxide nanoparticles (MoO₃ NPs) are extensively used in the biomedical, agricultural, and engineering fields that may increase exposure and adverse health effects to the human population. The purpose of this study is to evaluate a possible molecular mechanism leading to cell damage and death following pulmonary exposure to inhaled MoO₃ NPs. Animals were separated into four groups: two control groups exposed to room air or aerosolized water and two treated groups exposed to aerosolized MoO₃ NPs with a concentration of 5 mg/m³ NPs (4 h/day for eight days) and given a one-day (T-1) or seven-day (T-7) recovery period post exposure. Pulmonary toxicity was evaluated with total and differential cell counts. Increases were seen in total cell

SUBMITTER: Huber EA 

PROVIDER: S-EPMC9837300 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature