The landscape of metabolic brain alterations in Alzheimer's disease.

ABSTRACT:

Introduction

Alzheimer's disease (AD) is accompanied by metabolic alterations both in the periphery and the central nervous system. However, so far, a global view of AD-associated metabolic changes in the brain has been missing.

Methods

We metabolically profiled 500 samples from the dorsolateral prefrontal cortex. Metabolite levels were correlated with eight clinical parameters, covering both late-life cognitive performance and AD neuropathology measures.

Results

We observed widespread metabolic dysregulation associated with AD, spanning 298 metabolites from various AD-relevant pathways. These included alterations to bioenergetics, cholesterol metabolism, neuroinflammation, and metabolic consequences of neurotransmitter ratio imbalances. Our findings further suggest i

SUBMITTER: Batra R 

PROVIDER: S-EPMC9837312 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature