Disease Progression and Longitudinal Clinical Outcomes of Lewy Body Dementia in the NACC Database.

ABSTRACT:

Introduction

As the identification of Lewy body dementia (LBD) is often confirmed postmortem, there is a paucity of evidence on the progression of disease antemortem. This study aimed to comprehensively assess the course of LBD over time across cognitive, functional, and neuropsychiatric outcomes using real-world data.

Methods

Adults with at least one visit to an Alzheimer's Disease Center with a diagnosis of mild cognitive impairment/dementia (index date), indication of LBD, and at least one follow-up visit were identified in the National Alzheimer's Coordinating Center database (September 2005-June 2020). Participant characteristics, medication use, comorbidities, and changes in outcomes were assessed over a 5-year follow-up period and stratified by disease severity based

SUBMITTER: Chandler J 

PROVIDER: S-EPMC9837351 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature