Spatial transcriptome analysis of long non-coding RNAs reveals tissue specificity and functional roles in cancer.

ABSTRACT: Long non-coding RNAs (lncRNAs) play a significant role in maintaining tissue morphology and functions, and their precise regulatory effectiveness is closely related to expression patterns. However, the spatial expression patterns of lncRNAs in humans are poorly characterized. Here, we constructed five comprehensive transcriptomic atlases of human lncRNAs covering thousands of major tissue samples in normal and disease states. The lncRNA transcriptomes exhibited high consistency within the same tissues across resources, and even higher complexity in specialized tissues. Tissue-elevated (TE) lncRNAs were identified in each resource and robust TE lncRNAs were refined by integrative analysis. We detected 1 to 4684 robust TE lncRNAs across tissues; the highest number was in testis tissue, follo

SUBMITTER: Xu K 

PROVIDER: S-EPMC9837373 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature