Genomic profiling for clinical decision making in lymphoid neoplasms.

ABSTRACT: With the introduction of large-scale molecular profiling methods and high-throughput sequencing technologies, the genomic features of most lymphoid neoplasms have been characterized at an unprecedented scale. Although the principles for the classification and diagnosis of these disorders, founded on a multidimensional definition of disease entities, have been consolidated over the past 25 years, novel genomic data have markedly enhanced our understanding of lymphomagenesis and enriched the description of disease entities at the molecular level. Yet, the current diagnosis of lymphoid tumors is largely based on morphological assessment and immunophenotyping, with only few entities being defined by genomic criteria. This paper, which accompanies the International Consensus Classification of m

SUBMITTER: de Leval L 

PROVIDER: S-EPMC9837456 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature