Characterization of a P1-bacteriophage-like plasmid (phage-plasmid) harbouring bla _CTX-M-15 in Salmonella enterica serovar Typhi.

ABSTRACT: Antimicrobial-resistance (AMR) genes can be transferred between microbial cells via horizontal gene transfer (HGT), which involves mobile and integrative elements such as plasmids, bacteriophages, transposons, integrons and pathogenicity islands. Bacteriophages are found in abundance in the microbial world, but their role in virulence and AMR has not fully been elucidated in the Enterobacterales. With short-read sequencing paving the way to systematic high-throughput AMR gene detection, long-read sequencing technologies now enable us to establish how such genes are structurally connected into meaningful genomic units, raising questions about how they might cooperate to achieve their biological function. Here, we describe a novel ~98 kbp circular P1-bacteriophage-like plasmid termed

SUBMITTER: Greig DR 

PROVIDER: S-EPMC9837566 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature