Sex Is the Main Determinant of Levodopa Clinical Pharmacokinetics: Evidence from a Large Series of Levodopa Therapeutic Monitoring.

ABSTRACT:

Background

Different studies, mostly with limited cohorts, have suggested the effects of patients' characteristics on levodopa (LD) pharmacokinetics.

Objective

We primarily aimed at investigating in a large population the relationship between patients' features and LD kinetic variables, to assess the main demographic and clinical predictors of LD clinical pharmacokinetics.

Methods

The study was retrospective, based on data collected from subjects with parkinsonism on chronic LD undergoing LD therapeutic monitoring (TM). LD TM includes serial quantitative motor tests and blood samples to measure plasma drug concentrations after each subject's chronically taken first-morning LD dose intake.

Results

Five hundred patients, 308 males (61.6%), mean (SD) age of 65 (10

SUBMITTER: Contin M 

PROVIDER: S-EPMC9837688 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature