Project description:A subgroup of Posterior fossa ependymomas show reduced H3K27me3 are more invasive, exhibit poor prognosis and epigenetically deregulated genes converge on radial glial factors, suggesting developing cerebellar radial glia as candidate cells-of-origin.

2016-11-23 | GSE89451 | GEO

ACVR1-mutant posterior fossa ependymoma

Project description:Genomewide DNA methylation array profiling of nine posterior fossa ependymomas harboring activating mutations in ACVR1. Two samples clustered with the PFA subtype and demonstrated H3K27me3 loss by immunohistochemistry, while the remaining 7 showed retained H3K27me3 and formed a methylation cluster distinct from other ependymal tumors. For these previsouly unpublished cases, the Illumina Infinium EPIC 850k Human DNA Methylation Beadchip was used to obtain DNA methylation profiles across approximately 850,000 CpG sites of genomic DNA extracted from formalin-fixed, paraffin-embedded tumor tissue.

2022-05-01 | GSE196013 | GEO

Pro-inflammatory cytokines mediate the epithelial-to-mesenchymal-like transition of pediatric posterior fossa ependymoma.

Project description: Not available

| S-EPMC9270322 | biostudies-literature

Infantile ZFTA Fusion-Positive Tumor of the Posterior Fossa: Molecular Tumor Board.

Project description: Not available

| S-EPMC10309551 | biostudies-literature

Thoracic metastasis of a pediatric posterior fossa group A ependymoma: a rare case and literature review.

Project description: Not available

| S-EPMC12820817 | biostudies-literature

Immunohistochemical analysis of H3K27me3 demonstrates global reduction in group-A childhood posterior fossa ependymoma and is a powerful predictor of outcome.

Project description: Not available