Stroma-derived miR-214 coordinates tumor dissemination.

ABSTRACT:

Background

Tumor progression is based on a close interaction between cancer cells and Tumor MicroEnvironment (TME). Here, we focus on the role that Cancer Associated Fibroblasts (CAFs), Mesenchymal Stem Cells (MSCs) and microRNAs (miRs) play in breast cancer and melanoma malignancy.

Methods

We used public databases to investigate miR-214 expression in the stroma compartment of primary human samples and evaluated tumor formation and dissemination following tumor cell injections in miR-214 overexpressing (miR-214^over) and knock out (miR-214^ko) mice. In addition, we dissected the impact of Conditioned Medium (CM) or Extracellular Vesicles (EVs) derived from miR-214-rich or depleted stroma cells on cell metastatic traits.

Results

We evidence that the

SUBMITTER: Orso F 

PROVIDER: S-EPMC9837925 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature