Efficacy and safety of antibiotic therapy for post-Lyme disease? A systematic review and network meta-analysis.

ABSTRACT:

Background

At present, the pathogenesis of post-treatment Lyme disease (PTLDS) is not clear, so the treatment scheme of PTLDS, especially antibiotic treatment, is still controversial. This study aims to evaluate the efficacy of antibiotics in the treatment of PTLDS using network meta-analysis (NMA).

Methods

Following PRISMA guidelines, a systematic literature search was conducted on randomized controlled trials in PubMed, EMBASE, Web of Science and Cochrane Library (the literature was published from database inception through December 16, 2022). Using random effect model and fixed effect model. STATA17.0 software was used to evaluate the quality and heterogeneity of the included research literature.

Results

The system included 4 randomized controlled trials (485 subje

SUBMITTER: Zhang X 

PROVIDER: S-EPMC9838005 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature