Arginase-1 inhibition reduces migration ability and metastatic colonization of colon cancer cells.

ABSTRACT:

Background

Arginase-1 (ARG1), a urea cycle-related enzyme, catalyzes the hydrolysis of arginine to urea and ornithine, which regulates the proliferation, differentiation, and function of various cells. However, it is unclear whether ARG1 controls the progression and malignant alterations of colon cancer.

Methods

We established metastatic colonization mouse model and ARG1 overexpressing murine colon cancer CT26 cells to investigate whether activation of ARG1 was related to malignancy of colon cancer cells in vivo. Living cell numbers and migration ability of CT26 cells were evaluated in the presence of ARG inhibitor in vitro.

Results

Inhibition of arginase activity significantly suppressed the proliferation and migration ability of CT26 murine colon cancer cells in vit

SUBMITTER: Wang X 

PROVIDER: S-EPMC9838026 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature