Thrombin increases the expression of cholesterol 25-hydroxylase in rat astrocytes after spinal cord injury.

ABSTRACT: Astrocytes are important cellular centers of cholesterol synthesis and metabolism that help maintain normal physiological function at the organism level. Spinal cord injury results in aberrant cholesterol metabolism by astrocytes and excessive production of oxysterols, which have profound effects on neuropathology. 25-Hydroxycholesterol (25-HC), the main product of the membrane-associated enzyme cholesterol-25-hydroxylase (CH25H), plays important roles in mediating neuroinflammation. However, whether the abnormal astrocyte cholesterol metabolism induced by spinal cord injury contributes to the production of 25-HC, as well as the resulting pathological effects, remain unclear. In the present study, spinal cord injury-induced activation of thrombin was found to increase astrocyte CH25H expre

SUBMITTER: Chen C 

PROVIDER: S-EPMC9838143 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature