The role of crm-1 in ionizing radiation-induced nervous system dysfunction in Caenorhabditis elegans.

ABSTRACT: Ionizing radiation can cause changes in nervous system function. However, the underlying mechanism remains unclear. In this study, Caenorhabditis elegans (C. elegans) was irradiated with 75 Gy of ⁶⁰Co whole-body γ radiation. Behavioral indicators (head thrashes, touch avoidance, and foraging), and the development of dopaminergic neurons related to behavioral function, were evaluated to assess the effects of ionizing radiation on nervous system function in C. elegans. Various behaviors were impaired after whole-body irradiation and degeneration of dopamine neurons was observed. This suggests that 75 Gy of γ radiation is sufficient to induce nervous system dysfunction. The genes nhr-76 and crm-1, which are reported to be related to nervous system function in human and mouse, were

SUBMITTER: Long HQ 

PROVIDER: S-EPMC9838165 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature