CMTM6 is highly expressed in lung adenocarcinoma and can be used as a biomarker of a poor diagnosis.

ABSTRACT:

Background

CMTM6 which is chemokine-like factor (CKLF)-like Marvel transmembrane domain containing family member 6 is involved in the occurrence and progression of various tumors. However, the role of CMTM6 is still unclear in lung adenocarcinoma (LUAD).

Methods

Immunohistochemical, Western blotting and RT‒PCR methods were used to detect the expression of CMTM6 in LUAD. Cox regression and the Kaplan‒Meier method were performed to assess overall survival. Immunogenic features were evaluated according to immune cell infiltrations, immune checkpoints. The sensitivity to chemotherapy agents was estimated using the pRRophetic package.

Results

In LUAD, the expression of CMTM6 was obviously upregulated and was significantly associated with T stage (p = 0.008) and lymp

SUBMITTER: Jia D 

PROVIDER: S-EPMC9838204 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature