Diagnostic value and mechanism of plasma S100A1 protein in acute ischemic stroke: a prospective and observational study.

ABSTRACT:

Background

Plasma S100A1 protein is a novel inflammatory biomarker associated with acute myocardial infarction and neurodegenerative disease's pathophysiological mechanisms. This study aimed to determine the levels of this protein in patients with acute ischemic stroke early in the disease progression and to investigate its role in the pathogenesis of acute ischemic stroke.

Methods

A total of 192 participants from hospital stroke centers were collected for the study. Clinically pertinent data were recorded. The volume of the cerebral infarction was calculated according to the Pullicino formula. Multivariate logistic regression analysis was used to select independent influences. ROC curve was used to analyze the diagnostic value of AIS and TIA. The correlation between S100A1,

SUBMITTER: Hong G 

PROVIDER: S-EPMC9838205 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature