Dataset Information
Genomic characterization of invasive meningococcal X isolates from Brazil, 1992-2022.
Ontology highlight
ABSTRACT: Introduction
Invasive meningococcal disease (IMD) is a major health problem. Given the post-COVID-19 pandemic scenario with the loosening of the non-pharmacological measures to control the virus transmission and considering the observed global reduction of meningococcal vaccination coverage, an increase in IMD cases can be expected.Methodology
Using whole-genome sequencing, we characterized six Neisseria meningitidis serogroup X (MenX) isolates recovered from IMD cases in Brazil in the last 30 years.Results
The predominance (66.6%, 4/6) of ST2888 presenting fHbp 160, NHBA 129, NadA 21, and PorA 19,15 was found on isolates. Two novel STs, 15458 and 15477, were described.Conclusion
This study describes the circulation of MenX lineage ST2888 in Brazil, previously reported only in Europe. Continuous universal surveillance is crucial to implement prompt public health measures aiming to prevent and control non-vaccine preventable serogroup X IMD cases.
SUBMITTER: Cassiolato AP
PROVIDER: S-EPMC9838296 | biostudies-literature | 2023 Aug
REPOSITORIES: biostudies-literature
Publications
Genomic characterization of invasive meningococcal X isolates from Brazil, 1992-2022.
International microbiology : the official journal of the Spanish Society for Microbiology 20230110 3
<h4>Introduction</h4>Invasive meningococcal disease (IMD) is a major health problem. Given the post-COVID-19 pandemic scenario with the loosening of the non-pharmacological measures to control the virus transmission and considering the observed global reduction of meningococcal vaccination coverage, an increase in IMD cases can be expected.<h4>Methodology</h4>Using whole-genome sequencing, we characterized six Neisseria meningitidis serogroup X (MenX) isolates recovered from IMD cases in Brazil ...[more]
