Altered gut microbiota composition in children and their caregivers infected with the SARS-CoV-2 Omicron variant.

ABSTRACT:

Background

Gut microbiota alterations have been implicated in the pathogenesis of coronavirus disease 2019 (COVID-19). This study aimed to explore gut microbiota changes in a prospective cohort of COVID-19 children and their asymptomatic caregivers infected with the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) Omicron variant.

Methods

A total of 186 participants, including 59 COVID-19 children, 50 asymptomatic adult caregivers, 52 healthy children (HC), and 25 healthy adults (HA), were recruited between 15 April and 31 May 2022. The gut microbiota composition was determined by 16S rRNA gene sequencing in fecal samples collected from the participants. Gut microbiota functional profiling was performed by using Phylogenetic Investigation of Communities by R

SUBMITTER: Wang YZ 

PROVIDER: S-EPMC9838448 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature