Biomechanical activation of blood platelets via adhesion to von Willebrand factor studied with mesoscopic simulations.

ABSTRACT: Platelet adhesion and activation are essential initial processes of arterial and microvascular hemostasis, where high hydrodynamic forces from the bloodflow impede coagulation. The process relies on von Willebrand factor (VWF)-a linear multimeric protein of blood plasma plays a pivotal role in mechanochemical regulation of shear-induced platelet aggregation (SIPA). Adhesive interactions between VWF and glycoprotein receptors GPIb are crucial for platelet recruitment under high shear stress in fluid. Recent advances in experimental studies revealed that mechanical tension on the extracellular part of GPIb may trigger a cascade of biochemical reactions in platelets leading to activation of integrins [Formula: see text] (also known as GPIIb/IIIa) and strengthening of the adhesion. The present

SUBMITTER: Belyaev AV 

PROVIDER: S-EPMC9838538 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature