Modeling Wheezing Spells Identifies Phenotypes with Different Outcomes and Genetic Associates.

ABSTRACT: Rationale: Longitudinal modeling of current wheezing identified similar phenotypes, but their characteristics often differ between studies. Objectives: We propose that a more comprehensive description of wheeze may better describe trajectories than binary information on the presence/absence of wheezing. Methods: We derived six multidimensional variables of wheezing spells from birth to adolescence (including duration, temporal sequencing, and the extent of persistence/recurrence). We applied partition-around-medoids clustering on these variables to derive phenotypes in five birth cohorts. We investigated within- and between-phenotype differences compared with binary latent class analysis models and ascertained associations of these phenotypes with asthma and lung funct

SUBMITTER: Haider S 

PROVIDER: S-EPMC9838626 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature