Aerosol Electroanalysis by PILSNER: Particle-into-Liquid Sampling for Nanoliter Electrochemical Reactions.

ABSTRACT: Particle-into-liquid sampling (PILS) has enabled robust quantification of analytes of interest in aerosol particles. In PILS, the limit of detection is limited by the factor of particle dilution into the liquid sampling volume. Thus, much lower limits of detection can be achieved by decreasing the sampling volume and increasing the surface area-to-volume ratio of the collection substrate. Unfortunately, few analytical techniques can realize this miniaturization. Here, we use an ultramicroelectrode in a microliter or smaller sampling volume to detect redox active species in aerosols to develop the technique of Particle-into-Liquid Sampling for Nanoliter Electrochemical Reactions (PILSNER). As a proof-of-concept to validate this technique, we demonstrate the detection of K₄Fe(CN)<

SUBMITTER: Kauffmann PJ 

PROVIDER: S-EPMC9838725 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature