Distribution of an analgesic palmitoylethanolamide and other N-acylethanolamines in human placental membranes.

ABSTRACT:

Background

Human amniotic and amniochorionic membranes (AM, ACM) represent the most often used grafts accelerating wound healing. Palmitoylethanolamide, oleoylethanolamide and anandamide are endogenous bioactive lipid molecules, generally referred as N-acylethanolamines. They express analgesic, nociceptive, neuroprotective and anti-inflammatory properties. We assessed the distribution of these lipid mediators in placental tissues, as they could participate on analgesic and wound healing effect of AM/ACM grafts.

Methods

Seven placentas were collected after caesarean delivery and fresh samples of AM, ACM, placental disc, umbilical cord, umbilical serum and vernix caseosa, and decontaminated samples (antibiotic solution BASE 128) of AM and ACM have been prepared. Ultra-high-per

SUBMITTER: Svobodova A 

PROVIDER: S-EPMC9838831 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature